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old male icr mice  (Inotiv)


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    Inotiv old male icr mice
    Old Male Icr Mice, supplied by Inotiv, used in various techniques. Bioz Stars score: 95/100, based on 1483 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/old male icr mice/product/Inotiv
    Average 95 stars, based on 1483 article reviews
    old male icr mice - by Bioz Stars, 2026-06
    95/100 stars

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    Effects of DLE and MC on scratching behavior and serum histamine levels in compound 48/80 or chloroquine-injected <t>ICR</t> <t>mice.</t> (A) Scratching behavior for 30 min in the compound 48/80-injected group. (B) Scratching behavior for 30 min in the chloroquine-injected group. (C) Serum histamine levels in the compound 48/80-injected group. (D) Serum histamine levels in the chloroquine-injected group. Counting of scratching behavior was conducted through the double-blinded method. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin.
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    Effects of DLE and MC on scratching behavior and serum histamine levels in compound 48/80 or chloroquine-injected ICR mice. (A) Scratching behavior for 30 min in the compound 48/80-injected group. (B) Scratching behavior for 30 min in the chloroquine-injected group. (C) Serum histamine levels in the compound 48/80-injected group. (D) Serum histamine levels in the chloroquine-injected group. Counting of scratching behavior was conducted through the double-blinded method. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching

    doi: 10.3892/etm.2025.12871

    Figure Lengend Snippet: Effects of DLE and MC on scratching behavior and serum histamine levels in compound 48/80 or chloroquine-injected ICR mice. (A) Scratching behavior for 30 min in the compound 48/80-injected group. (B) Scratching behavior for 30 min in the chloroquine-injected group. (C) Serum histamine levels in the compound 48/80-injected group. (D) Serum histamine levels in the chloroquine-injected group. Counting of scratching behavior was conducted through the double-blinded method. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin.

    Article Snippet: Male ICR mice (4 weeks old, specific-pathogen-free) were purchased from Orient Bio Inc. (Gwangju, South Korea).

    Techniques: Injection, Control

    Effects of DLE and MC on mast cell infiltration in compound 48/80 or chloroquine-injected ICR mice. Representative toluidine blue staining images of skin with red arrows indicating stained mast cells (scale bar, 200 µm). The graph shows the number of mast cells counted in mice injected with (A) compound 48/80 and (B) chloroquine. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching

    doi: 10.3892/etm.2025.12871

    Figure Lengend Snippet: Effects of DLE and MC on mast cell infiltration in compound 48/80 or chloroquine-injected ICR mice. Representative toluidine blue staining images of skin with red arrows indicating stained mast cells (scale bar, 200 µm). The graph shows the number of mast cells counted in mice injected with (A) compound 48/80 and (B) chloroquine. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin.

    Article Snippet: Male ICR mice (4 weeks old, specific-pathogen-free) were purchased from Orient Bio Inc. (Gwangju, South Korea).

    Techniques: Injection, Staining, Control

    Effects of DLE and MC on spinal cord GRPR in compound 48/80 or chloroquine-injected ICR mice. Spinal cord immunofluorescence stained with antibodies against GRPR (green) in mice injected with (A) compound 48/80 and (B) chloroquine (scale bar, 40 µm). (C) Western blotting data showing the expression of GRPR in the spinal cord tissue for both compound 48/80 and chloroquine-injected mice. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; GRPR, gastrin-releasing peptide receptor.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching

    doi: 10.3892/etm.2025.12871

    Figure Lengend Snippet: Effects of DLE and MC on spinal cord GRPR in compound 48/80 or chloroquine-injected ICR mice. Spinal cord immunofluorescence stained with antibodies against GRPR (green) in mice injected with (A) compound 48/80 and (B) chloroquine (scale bar, 40 µm). (C) Western blotting data showing the expression of GRPR in the spinal cord tissue for both compound 48/80 and chloroquine-injected mice. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; GRPR, gastrin-releasing peptide receptor.

    Article Snippet: Male ICR mice (4 weeks old, specific-pathogen-free) were purchased from Orient Bio Inc. (Gwangju, South Korea).

    Techniques: Injection, Immunofluorescence, Staining, Western Blot, Expressing, Control

    Effects of DLE and MC on spinal cord IL-31RA in compound 48/80 or chloroquine-injected ICR mice. Spinal cord immunofluorescence stained with antibodies against IL-31RA (green) in mice injected with (A) compound 48/80 and (B) chloroquine (scale bar, 40 µm). (C) Western blotting data showing the expression of IL-31RA in the spinal cord tissue for both compound 48/80 and chloroquine-injected mice. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; IL-31RA, interleukin-31 receptor A.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching

    doi: 10.3892/etm.2025.12871

    Figure Lengend Snippet: Effects of DLE and MC on spinal cord IL-31RA in compound 48/80 or chloroquine-injected ICR mice. Spinal cord immunofluorescence stained with antibodies against IL-31RA (green) in mice injected with (A) compound 48/80 and (B) chloroquine (scale bar, 40 µm). (C) Western blotting data showing the expression of IL-31RA in the spinal cord tissue for both compound 48/80 and chloroquine-injected mice. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; IL-31RA, interleukin-31 receptor A.

    Article Snippet: Male ICR mice (4 weeks old, specific-pathogen-free) were purchased from Orient Bio Inc. (Gwangju, South Korea).

    Techniques: Injection, Immunofluorescence, Staining, Western Blot, Expressing, Control

    Effects of DLE and MC on spinal cord STAT3 in compound 48/80 or chloroquine-injected ICR mice. Spinal cord immunofluorescence stained with antibodies against STAT3 (green) in mice injected with (A) compound 48/80 and (B) chloroquine (scale bar, 40 µm). (C) Western blotting data showing the expression of STAT3 in the spinal cord tissue for both compound 48/80 and chloroquine-injected mice. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; p-, phosphorylated.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching

    doi: 10.3892/etm.2025.12871

    Figure Lengend Snippet: Effects of DLE and MC on spinal cord STAT3 in compound 48/80 or chloroquine-injected ICR mice. Spinal cord immunofluorescence stained with antibodies against STAT3 (green) in mice injected with (A) compound 48/80 and (B) chloroquine (scale bar, 40 µm). (C) Western blotting data showing the expression of STAT3 in the spinal cord tissue for both compound 48/80 and chloroquine-injected mice. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; p-, phosphorylated.

    Article Snippet: Male ICR mice (4 weeks old, specific-pathogen-free) were purchased from Orient Bio Inc. (Gwangju, South Korea).

    Techniques: Injection, Immunofluorescence, Staining, Western Blot, Expressing, Control

    Effects of DLE and MC on serum and skin IL-31 levels in compound 48/80 or chloroquine-injected ICR mice. (A) Serum IL-31 levels in the compound 48/80-injected group. (B) Serum IL-31 levels in the chloroquine-injected group. (C) IL-31 expression in dorsal skin tissue of compound 48/80-injected group. (D) IL-31 expression in dorsal skin tissue of chloroquine-injected group. IL-31 levels were measured using ELISA and western blot. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; IL-31, interleukin-31.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine‑dependent and histamine‑independent itching

    doi: 10.3892/etm.2025.12871

    Figure Lengend Snippet: Effects of DLE and MC on serum and skin IL-31 levels in compound 48/80 or chloroquine-injected ICR mice. (A) Serum IL-31 levels in the compound 48/80-injected group. (B) Serum IL-31 levels in the chloroquine-injected group. (C) IL-31 expression in dorsal skin tissue of compound 48/80-injected group. (D) IL-31 expression in dorsal skin tissue of chloroquine-injected group. IL-31 levels were measured using ELISA and western blot. Each bar represents the mean ± SD (n=5). # P<0.05 vs. normal group. * P<0.05 vs. control group. DLE, D. lotus leaf extract; MC, myricitrin; IL-31, interleukin-31.

    Article Snippet: Male ICR mice (4 weeks old, specific-pathogen-free) were purchased from Orient Bio Inc. (Gwangju, South Korea).

    Techniques: Injection, Expressing, Enzyme-linked Immunosorbent Assay, Western Blot, Control